Timo Burster

Activation of Cytotoxic Natural Killer Cells After Aneurysmal Subarachnoid Hemorrhage
Spitzer, D., Spitzer, N., Deininger, M., Wirtz, C., König, R., Burster, T., Kapapa, T., 2017 In : World Neurosurgery. 101, p. 666-676.e1

Spliced analogues of trypsin inhibitor SFTI-1 and their application for tracing proteolysis and delivery of cargos inside the cells
Filipowicz, M., Ptaszyńska, N., Olkiewicz, K., Dębowski, D., Ćwikłowska, K., Burster, T., Pikuła, M., Krzystyniak, A., Łęgowska, A., Rolka, K., 2017 In : Biopolymers. 108, 2,

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells
Bischof, J., Westhoff, M., Wagner, J., Halatsch, M., Trentmann, S., Knippschild, U., Wirtz, C., Burster, T., 2017 In : Tumor Biology. 39, 3, p. 1010428317692227

Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples
Łęgowska, M., Hamon, Y., Wojtysiak, A., Grzywa, R., Sieńczyk, M., Burster, T., Korkmaz, B., Lesner, A., 2016 In : Archives of Biochemistry and Biophysics. 612, p. 91-102

Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells
Giese, M., Turiello, N., Molenda, N., Palesch, D., Meid, A., Schroeder, R., Basilico, P., Benarafa, C., Halatsch, M., Zimecki, M., Westhoff, M., Wirtz, C., Burster, T., 2016 In : Oncotarget. 7, 46, p. 74602-74611

Cell surface cathepsin G activity differs between human natural killer cell subsets
Penczek, A., Sienczyk, M., Wirtz, C., Burster, T., 2016 In : Immunology Letters. 179, p. 80-84

Immune phenotypes predict survival in patients with glioblastoma multiforme
Mostafa, H., Pala, A., Högel, J., Hlavac, M., Dietrich, E., Westhoff, M., Nonnenmacher, L., Burster, T., Georgieff, M., Wirtz, C., Schneider, E., 2016 In : Journal of Hematology and Oncology. 9, 1, p. 77

Cathepsin G-mediated proteolytic degradation of MHC class I molecules to facilitate immune detection of human glioblastoma cells
Palesch, D., Wagner, J., Meid, A., Molenda, N., Sienczyk, M., Burkhardt, J., Münch, J., Prokop, L., Stevanovic, S., Westhoff, M., Halatsch, M., Wirtz, C., Zimecki, M., Burster, T., 2016 In : Cancer Immunology and Immunotherapy. 65, 3, p. 283-91

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G
Eipper, S., Steiner, R., Lesner, A., Sienczyk, M., Palesch, D., Halatsch, M., Zaczynska, E., Heim, C., Hartmann, M., Zimecki, M., Wirtz, C., Burster, T., 2016 In : PLoS One. 11, 3, p. e0151509

Cell Death Induction in Cancer Therapy - Past, Present, and Future
Nonnenmacher, L., Hasslacher, S., Zimmermann, J., Karpel-Massler, G., La Ferla-Brühl, K., Barry, S., Burster, T., Siegelin, M., Brühl, O., Halatsch, M., Debatin, K., Westhoff, M., 2016 In : Critical Reviews in Oncogenesis. 21, 3-4, p. 253-267

Discovery and characterization of an endogenous CXCR4 antagonist
Zirafi, O., Kim, K., Ständker, L., Mohr, K., Sauter, D., Heigele, A., Kluge, S., Wiercinska, E., Chudziak, D., Richter, R., Moepps, B., Gierschik, P., Vas, V., Geiger, H., Lamla, M., Weil, T., Burster, T., Zgraja, A., Daubeuf, F., Frossard, N., Hachet-Haas, M., Heunisch, F., Reichetzeder, C., Galzi, J., Pérez-Castells, J., Canales-Mayordomo, A., Jiménez-Barbero, J., Giménez-Gallego, G., Schneider, M., Shorter, J., Telenti, A., Hocher, B., Forssmann, W., Bonig, H., Kirchhoff, F., Münch, J., 2015 In : Cell Reports. 11, 5, p. 737-47

CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application
Winkler, B., Oltmer, F., Richter, J., Bischof, J., Xu, P., Burster, T., Leithäuser, F., Knippschild, U., 2015 In : Frontiers in Cell and Developmental Biology. 3, p. 9

Ultrasensitive internally quenched substrates of human cathepsin L
Lęgowska, M., Wysocka, M., Burster, T., Pikuła, M., Rolka, K., Lesner, A., 2014 In : Analytical Biochemistry. 466, p. 30-7

Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms
Grzywa, R., Burchacka, E., Łęcka, M., Winiarski, Ł., Walczak, M., Łupicka-Słowik, A., Wysocka, M., Burster, T., Bobrek, K., Csencsits-Smith, K., Lesner, A., Sieńczyk, M., 2014 In : ChemBioChem. 15, 17, p. 2605-12

Processing and regulation mechanisms within antigen presenting cells: a possibility for therapeutic modulation
Burster, T., 2013 In : Current Pharmaceutical Design. 19, 6, p. 1029-42

N- and C-terminal degradation of ecdysteroid receptor isoforms, when transiently expressed in mammalian CHO cells, is regulated by the proteasome and cysteine and threonine proteases
Schauer, S., Burster, T., Spindler-Barth, M., 2012 In : Insect Molecular Biology. 21, 3, p. 383-94

Cathepsin S dominates autoantigen processing in human thymic dendritic cells
Stoeckle, C., Quecke, P., Rückrich, T., Burster, T., Reich, M., Weber, E., Kalbacher, H., Driessen, C., Melms, A., Tolosa, E., 2012 In : Journal of Autoimmunity. 38, 4, p. 332-43

Application of a novel highly sensitive activity-based probe for detection of cathepsin G
Zou, F., Schmon, M., Sienczyk, M., Grzywa, R., Palesch, D., Boehm, B., Sun, Z., Watts, C., Schirmbeck, R., Burster, T., 2012 In : Analytical Biochemistry. 421, 2, p. 667-72

Was the serine protease cathepsin G discovered by S. G. Hedin in 1903 in bovine spleen?
Palesch, D., Sieńczyk, M., Oleksyszyn, J., Reich, M., Wieczerzak, E., Boehm, B., Burster, T., 2011 In : Acta Biochimica Polonica. 58, 1, p. 39-44

Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients
Zou, F., Schäfer, N., Palesch, D., Brücken, R., Beck, A., Sienczyk, M., Kalbacher, H., Sun, Z., Boehm, B., Burster, T., 2011 In : PLoS One. 6, 8, p. e22815

Invariant chain processing is independent of cathepsin variation between primary human B cells/dendritic cells and B-lymphoblastoid cells
Reich, M., Zou, F., Sieńczyk, M., Oleksyszyn, J., Boehm, B., Burster, T., 2011 In : Cellular Immunology. 269, 2, p. 96-103

Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules
Burster, T., Macmillan, H., Hou, T., Schilling, J., Truong, P., Boehm, B., Zou, F., Lau, K., Strohman, M., Schaffert, S., Busch, R., Mellins, E., 2010 In : Immunology. 130, 3, p. 436-46

Processing and presentation of (pro)-insulin in the MHC class II pathway: the generation of antigen-based immunomodulators in the context of type 1 diabetes mellitus
Burster, T., Boehm, B., 2010 In : Diabetes/Metabolism Research and Reviews. 26, 4, p. 227-38

A proinsulin 74-90-derived protease-resistant, altered peptide ligand increases TGF-beta 1 secretion in PBMC from patients with type 1 diabetes mellitus
van Aalst, D., Kalbacher, H., Palesch, D., Zou, F., Spyrantis, A., Rosinger, S., Boehm, B., Burster, T., 2010 In : Journal of Leukocyte Biology. 87, 5, p. 943-8

Cathepsin A is expressed in primary human antigen-presenting cells
Reich, M., Spindler, K., Burret, M., Kalbacher, H., Boehm, B., Burster, T., 2010 In : Immunology Letters. 128, 2, p. 143-7

Cathepsin G: roles in antigen presentation and beyond
Burster, T., Macmillan, H., Hou, T., Boehm, B., Mellins, E., 2010 In : Molecular Immunology. 47, 4, p. 658-65

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells
Reich, M., Lesner, A., Legowska, A., Sieńczyk, M., Oleksyszyn, J., Boehm, B., Burster, T., 2009 In : Molecular Immunology. 46, 15, p. 2994-9

Protease-resistant human GAD-derived altered peptide ligands decrease TNF-alpha and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus
Boehm, B., Rosinger, S., Sauer, G., Manfras, B., Palesch, D., Schiekofer, S., Kalbacher, H., Burster, T., 2009 In : Molecular Immunology. 46, 13, p. 2576-84

Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells
Reich, M., Wieczerzak, E., Jankowska, E., Palesch, D., Boehm, B., Burster, T., 2009 In : Immunology Letters. 123, 2, p. 155-9

Cathepsin G is differentially expressed in primary human antigen-presenting cells
Stoeckle, C., Sommandas, V., Adamopoulou, E., Belisle, K., Schiekofer, S., Melms, A., Weber, E., Driessen, C., Boehm, B., Tolosa, E., Burster, T., 2009 In : Cellular Immunology. 255, 1-2, p. 41-5

Cathepsin E regulates the presentation of tetanus toxin C-fragment in PMA activated primary human B cells
Burster, T., Reich, M., Zaidi, N., Voelter, W., Boehm, B., Kalbacher, H., 2008 In : Biochemical and Biophysical Research Communications. 377, 4, p. 1299-303

Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells
Schiekofer, S., Belisle, K., Galasso, G., Schneider, J., Boehm, B., Burster, T., Schmitz, G., Walsh, K., 2008 In : Angiogenesis. 11, 3, p. 289-99

A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A
Zaidi, N., Burster, T., Sommandas, V., Herrmann, T., Boehm, B., Driessen, C., Voelter, W., Kalbacher, H., 2007 In : Biochemical and Biophysical Research Communications. 364, 2, p. 243-9

Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions
Burster, T., Marin-Esteban, V., Boehm, B., Dunn, S., Rotzschke, O., Falk, K., Weber, E., Verhelst, S., Kalbacher, H., Driessen, C., 2007 In : Biochemical Pharmacology. 74, 10, p. 1514-23

Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro
Burster, T., Beck, A., Poeschel, S., Øren, A., Baechle, D., Reich, M., Roetzschke, O., Falk, K., Boehm, B., Youssef, S., Kalbacher, H., Overkleeft, H., Tolosa, E., Driessen, C., 2007 In : Immunology. 121, 1, p. 82-93

Influenza A virus elevates active cathepsin B in primary murine DC
Burster, T., Giffon, T., Dahl, M., Björck, P., Bogyo, M., Weber, E., Mahmood, K., Lewis, D., Mellins, E., 2007 In : International Immunology. 19, 5, p. 645-55

Human cytomegalovirus alters localization of MHC class II and dendrite morphology in mature Langerhans cells
Lee, A., Hertel, L., Louie, R., Burster, T., Lacaille, V., Pashine, A., Abate, D., Mocarski, E., Mellins, E., 2006 In : Journal of Immunology. 177, 6, p. 3960-71

Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation
Hornell, T., Burster, T., Jahnsen, F., Pashine, A., Ochoa, M., Harding, J., Macaubas, C., Lee, A., Modlin, R., Mellins, E., 2006 In : Journal of Immunology. 176, 6, p. 3536-47

Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells
Burster, T., Beck, A., Tolosa, E., Schnorrer, P., Weissert, R., Reich, M., Kraus, M., Kalbacher, H., Häring, H., Weber, E., Overkleeft, H., Driessen, C., 2005 In : Journal of Immunology. 175, 9, p. 5940-9

Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression
Busch, R., Rinderknecht, C., Roh, S., Lee, A., Harding, J., Burster, T., Hornell, T., Mellins, E., 2005 In : Immunological Reviews. 207, p. 242-60

Biotinylated fluorescent peptide substrates for the sensitive and specific determination of cathepsin D activity
Baechle, D., Cansier, A., Fischer, R., Brandenburg, J., Burster, T., Driessen, C., Kalbacher, H., 2005 In : Journal of Peptide Science. 11, 3, p. 166-74

Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes
Burster, T., Beck, A., Tolosa, E., Marin-Esteban, V., Rötzschke, O., Falk, K., Lautwein, A., Reich, M., Brandenburg, J., Schwarz, G., Wiendl, H., Melms, A., Lehmann, R., Stevanovic, S., Kalbacher, H., Driessen, C., 2004 In : Journal of Immunology. 172, 9, p. 5495-503

Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner
Lautwein, A., Kraus, M., Reich, M., Burster, T., Brandenburg, J., Overkleeft, H., Schwarz, G., Kammer, W., Weber, E., Kalbacher, H., Nordheim, A., Driessen, C., 2004 In : Journal of Leukocyte Biology. 75, 5, p. 844-55

Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells
Lautwein, A., Burster, T., Lennon-Duménil, A., Overkleeft, H., Weber, E., Kalbacher, H., Driessen, C., 2002 In : European Journal of Immunology. 32, 12, p. 3348-57

Characterization of legumain
Schwarz, G., Brandenburg, J., Reich, M., Burster, T., Driessen, C., Kalbacher, H., 2002 In : Biological Chemistry. 383, 11, p. 1813-6

Cathepsin S activity is detectable in human keratinocytes and is selectively upregulated upon stimulation with interferon-gamma
Schwarz, G., Boehncke, W., Braun, M., Schröter, C., Burster, T., Flad, T., Dressel, D., Weber, E., Schmid, H., Kalbacher, H., 2002 In : Journal of Investigative Dermatology. 119, 1, p. 44-9