Prim Singh

Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization
Bosch-Presegué, L., Raurell-Vila, H., Thackray, J., González, J., Casal, C., Kane-Goldsmith, N., Vizoso, M., Brown, J., Gómez, A., Ausió, J., Zimmermann, T., Esteller, M., Schotta, G., Singh, P., Serrano, L., Vaquero, A., 2017 In : Cell Reports. 21, 8, p. 2048-2057

Activity-DEPendent Transposition
Newman, A., Bessa, P., Tarabykin, V., Singh, P., 2017 In : EMBO Reports. 18, 3, p. 346-348

An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions
Raurell-Vila, H., Bosch-Presegue, L., Gonzalez, J., Kane-Goldsmith, N., Casal, C., Brown, J., Marazuela-Duque, A., Singh, P., Serrano, L., Vaquero, A., 2017 In : Epigenetics. 12, 2, p. 166-175

Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals
Singh, P., 2016 In : Journal of Biosciences. 41, 4, p. 759-786

Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3-H4 histones and lamin-B receptor
Cardinale, A., Filesi, I., Singh, P., Biocca, S., 2015 In : Experimental Cell Research. 338, 1, p. 70-81

Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells
Mattout, A., Aaronson, Y., Sailaja, B., Raghu Ram, E., Harikumar, A., Mallm, J., Sim, K., Nissim-Rafinia, M., Supper, E., Singh, P., Sze, S., Gasser, S., Rippe, K., Meshorer, E., 2015 In : Genome Biology. 16, p. 213

A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects
Aydin, E., Kloos, D., Gay, E., Jonker, W., Hu, L., Bullwinkel, J., Brown, J., Manukyan, M., Giera, M., Singh, P., Fundele, R., 2015 In : Journal of Biosciences. 40, 2, p. 325-38

Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells
Maksakova, I., Thompson, P., Goyal, P., Jones, S., Singh, P., Karimi, M., Lorincz, M., 2013 In : Epigenetics and Chromatin. 6, 1, p. 15

Epigenetic rejuvenation
Manukyan, M., Singh, P., 2012 In : Genes to Cells. 17, 5, p. 337-43

H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing
Maksakova, I., Goyal, P., Bullwinkel, J., Brown, J., Bilenky, M., Mager, D., Singh, P., Lorincz, M., 2011 In : Epigenetics and Chromatin. 4, 1, p. 12

HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats
Mosch, K., Franz, H., Soeroes, S., Singh, P., Fischle, W., 2011 In : PLoS One. 6, 1, p. e15894

Epigenotype switching at the CD14 and CD209 genes during differentiation of human monocytes to dendritic cells
Bullwinkel, J., Lüdemann, A., Debarry, J., Singh, P., 2011 In : Epigenetics. 6, 1, p. 45-51

HP1 proteins--what is the essential interaction?
Singh, P., 2010 In : Genetika. 46, 10, p. 1424-9

Nuclear reprogramming and epigenetic rejuvenation
Singh, P., Zacouto, F., 2010 In : Journal of Biosciences. 35, 2, p. 315-9

HP1gamma function is required for male germ cell survival and spermatogenesis
Brown, J., Bullwinkel, J., Baron-Lühr, B., Billur, M., Schneider, P., Winking, H., Singh, P., 2010 In : Epigenetics and Chromatin. 3, 1, p. 9

The essential function of HP1 beta: a case of the tail wagging the dog?
Billur, M., Bartunik, H., Singh, P., 2010 In : Trends in Biochemical Sciences. 35, 2, p. 115-23

Transcriptional regulation of mouse mast cell protease-2 by interleukin-15
Mirghomizadeh, F., Bullwinkel, J., Orinska, Z., Janssen, O., Petersen, A., Singh, P., Bulfone-Paus, S., 2009 In : Journal of Biological Chemistry. 284, 47, p. 32635-41

HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions
Aucott, R., Bullwinkel, J., Yu, Y., Shi, W., Billur, M., Brown, J., Menzel, U., Kioussis, D., Wang, G., Reisert, I., Weimer, J., Pandita, R., Sharma, G., Pandita, T., Fundele, R., Singh, P., 2008 In : Journal of Cell Biology. 183, 4, p. 597-606

gammaH2AX foci form preferentially in euchromatin after ionising-radiation
Cowell, I., Sunter, N., Singh, P., Austin, C., Durkacz, B., Tilby, M., 2007 In : PLoS One. 2, 10, p. e1057

Plasticity of HP1 proteins in mammalian cells
Dialynas, G., Terjung, S., Brown, J., Aucott, R., Baron-Luhr, B., Singh, P., Georgatos, S., 2007 In : Journal of Cell Science. 120, Pt 19, p. 3415-24

Interleukin-21: a new modulator of immunity, infection, and cancer
Brandt, K., Singh, P., Bulfone-Paus, S., Rückert, R., 2007 In : Cytokine and Growth Factor Reviews. 18, 3-4, p. 223-32

Epigenetic regulation of facultative heterochromatinisation in Planococcus citri via the Me(3)K9H3-HP1-Me(3)K20H4 pathway
Bongiorni, S., Pasqualini, B., Taranta, M., Singh, P., Prantera, G., 2007 In : Journal of Cell Science. 120, Pt 6, p. 1072-80

Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes
Takada, Y., Isono, K., Shinga, J., Turner, J., Kitamura, H., Ohara, O., Watanabe, G., Singh, P., Kamijo, T., Jenuwein, T., Burgoyne, P., Koseki, H., 2007 In : Development. 134, 3, p. 579-90

Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin
Wu, R., Singh, P., Gilbert, D., 2006 In : Journal of Cell Biology. 174, 2, p. 185-94

Methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin
Dialynas, G., Makatsori, D., Kourmouli, N., Theodoropoulos, P., McLean, K., Terjung, S., Singh, P., Georgatos, S., 2006 In : Journal of Biological Chemistry. 281, 20, p. 14350-60

Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1
Kourmouli, N., Sun, Y., van der Sar, S., Singh, P., Brown, J., 2005 In : Biochemical and Biophysical Research Communications. 337, 3, p. 901-7

Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states
Wu, R., Terry, A., Singh, P., Gilbert, D., 2005 In : Molecular Biology of the Cell. 16, 6, p. 2872-81

Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution
Badugu, R., Yoo, Y., Singh, P., Kellum, R., 2005 In : Chromosoma. 113, 7, p. 370-84

NF-Y regulates the antisense promoter, bidirectional silencing, and differential epigenetic marks of the Kcnq1 imprinting control region
Pandey, R., Ceribelli, M., Singh, P., Ericsson, J., Mantovani, R., Kanduri, C., 2004 In : Journal of Biological Chemistry. 279, 50, p. 52685-93

Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence
Grigoryev, S., Nikitina, T., Pehrson, J., Singh, P., Woodcock, C., 2004 In : Journal of Cell Science. 117, Pt 25, p. 6153-62

Messenger RNA electroporation is highly efficient in mouse embryonic stem cells: successful FLPe- and Cre-mediated recombination
Ponsaerts, P., Brown, J., Van den Plas, D., Van den Eeden, L., Van Bockstaele, D., Jorens, P., Van Tendeloo, V., Merregaert, J., Singh, P., Berneman, Z., 2004 In : Gene Therapy. 11, 21, p. 1606-10

The inner nuclear membrane protein lamin B receptor forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelope
Makatsori, D., Kourmouli, N., Polioudaki, H., Shultz, L., McLean, K., Theodoropoulos, P., Singh, P., Georgatos, S., 2004 In : Journal of Biological Chemistry. 279, 24, p. 25567-73

Heterochromatin and tri-methylated lysine 20 of histone H4 in animals
Kourmouli, N., Jeppesen, P., Mahadevhaiah, S., Burgoyne, P., Wu, R., Gilbert, D., Bongiorni, S., Prantera, G., Fanti, L., Pimpinelli, S., Shi, W., Fundele, R., Singh, P., 2004 In : Journal of Cell Science. 117, Pt 12, p. 2491-501

In vivo dynamics of Swi6 in yeast: evidence for a stochastic model of heterochromatin
Cheutin, T., Gorski, S., May, K., Singh, P., Misteli, T., 2004 In : Molecular and Cellular Biology. 24, 8, p. 3157-67

Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells
Xin, H., Yoon, H., Singh, P., Wong, J., Qin, J., 2004 In : Journal of Biological Chemistry. 279, 10, p. 9539-46

Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana
Jackson, J., Johnson, L., Jasencakova, Z., Zhang, X., PerezBurgos, L., Singh, P., Cheng, X., Schubert, I., Jenuwein, T., Jacobsen, S., 2004 In : Chromosoma. 112, 6, p. 308-15

Mitotic phosphorylation of histone H3 at threonine 3
Polioudaki, H., Markaki, Y., Kourmouli, N., Dialynas, G., Theodoropoulos, P., Singh, P., Georgatos, S., 2004 In : FEBS Letters. 560, 1-3, p. 39-44

Highly efficient mRNA-based gene transfer in feeder-free cultured H9 human embryonic stem cells
Ponsaerts, P., van der Sar, S., Van Tendeloo, V., Jorens, P., Berneman, Z., Singh, P., 2004 In : Cellular Reprogramming. 6, 3, p. 211-6

Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT
Istomina, N., Shushanov, S., Springhetti, E., Karpov, V., Krasheninnikov, I., Stevens, K., Zaret, K., Singh, P., Grigoryev, S., 2003 In : Molecular and Cellular Biology. 23, 18, p. 6455-68

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa
Tamaru, H., Zhang, X., McMillen, D., Singh, P., Nakayama, J., Grewal, S., Allis, C., Cheng, X., Selker, E., 2003 In : Nature Genetics. 34, 1, p. 75-9

Composite cis-acting epigenetic switches in eukaryotes: lessons from Drosophila Fab-7 for the Igf2-H19 imprinted domain
Brown, J., Singh, P., Cowell, I., 2003 In : Genetica. 117, 2-3, p. 199-207

Maintenance of stable heterochromatin domains by dynamic HP1 binding
Cheutin, T., McNairn, A., Jenuwein, T., Gilbert, D., Singh, P., Misteli, T., 2003 In : Science. 299, 5607, p. 721-5

HP1: facts, open questions, and speculation
Singh, P., Georgatos, S., 2002 In : Journal of Structural Biology. 140, 1-3, p. 10-6

Maternal regulation of imprinting
Kathirvel, P., Singh, P., 2002 In : Journal of Biosciences. 27, 5, p. 437-8

Crystallization and preliminary crystallographic studies on the chromo shadow domain (CSD) of mouse heterochromatin protein M31
Gao, Y., Ding, Y., Singh, P., Rao, Z., 2002 In : Acta Crystallographica Section D: Structural Biology. 58, Pt 6 Pt 2, p. 1051-3

Loss of heterochromatin protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death
Filesi, I., Cardinale, A., van der Sar, S., Cowell, I., Singh, P., Biocca, S., 2002 In : Journal of Cell Science. 115, Pt 9, p. 1803-13

Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals
Cowell, I., Aucott, R., Mahadevaiah, S., Burgoyne, P., Huskisson, N., Bongiorni, S., Prantera, G., Fanti, L., Pimpinelli, S., Wu, R., Gilbert, D., Shi, W., Fundele, R., Morrison, H., Jeppesen, P., Singh, P., 2002 In : Chromosoma. 111, 1, p. 22-36

The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure
Scholzen, T., Endl, E., Wohlenberg, C., van der Sar, S., Cowell, I., Gerdes, J., Singh, P., 2002 In : Journal of Pathology. 196, 2, p. 135-44

Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1
Polioudaki, H., Kourmouli, N., Drosou, V., Bakou, A., Theodoropoulos, P., Singh, P., Giannakouros, T., Georgatos, S., 2001 In : EMBO Reports. 2, 10, p. 920-5

M31 and macroH2A1.2 colocalise at the pseudoautosomal region during mouse meiosis
Turner, J., Burgoyne, P., Singh, P., 2001 In : Journal of Cell Science. 114, Pt 18, p. 3367-75

Binding of heterochromatin protein 1 to the nuclear envelope is regulated by a soluble form of tubulin
Kourmouli, N., Dialynas, G., Petraki, C., Pyrpasopoulou, A., Singh, P., Georgatos, S., Theodoropoulos, P., 2001 In : Journal of Biological Chemistry. 276, 16, p. 13007-14

Chemosensation and genetic individuality
Singh, P., 2001 In : Reproduction. 121, 4, p. 529-39

The gene and pseudogenes of Cbx3/mHP1 gamma
Jones, D., Mattei, M., Horsley, D., Cowell, I., Singh, P., 2001 In : DNA Sequence - Journal of DNA Sequencing and Mapping. 12, 3, p. 147-60

Dynamic associations of heterochromatin protein 1 with the nuclear envelope
Kourmouli, N., Theodoropoulos, P., Dialynas, G., Bakou, A., Politou, A., Cowell, I., Singh, P., Georgatos, S., 2000 In : EMBO Journal. 19, 23, p. 6558-68

Conservation of heterochromatin protein 1 function
Wang, G., Ma, A., Chow, C., Horsley, D., Brown, N., Cowell, I., Singh, P., 2000 In : Molecular and Cellular Biology. 20, 18, p. 6970-83

Mammalian chromodomain proteins: their role in genome organisation and expression
Jones, D., Cowell, I., Singh, P., 2000 In : BioEssays. 22, 2, p. 124-37

Embryonic inheritance of the chromatin organisation of the imprinted H19 domain in mouse spermatozoa
Banerjee, S., Singh, P., Rasberry, C., Cattanach, B., 2000 In : Mechanisms of Development. 90, 2, p. 217-26

The murine heterochromatin protein M31 is associated with the chromocenter in round spermatids and Is a component of mature spermatozoa
Hoyer-Fender, S., Singh, P., Motzkus, D., 2000 In : Experimental Cell Research. 254, 1, p. 72-9

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner
Festenstein, R., Sharghi-Namini, S., Fox, M., Roderick, K., Tolaini, M., Norton, T., Saveliev, A., Kioussis, D., Singh, P., 1999 In : Nature Genetics. 23, 4, p. 457-61

The present status of the 'carrier hypothesis' for chemosensory recognition of genetic individuality
Singh, P., 1999 In : Genetica. 104, 3, p. 231-3

Soluble MHC antigens and olfactory recognition of genetic individuality: the mechanism
Pearse-Pratt, R., Schellinck, H., Brown, R., Singh, P., Roser, B., 1999 In : Genetica. 104, 3, p. 223-30

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing
Ryan, R., Schultz, D., Ayyanathan, K., Singh, P., Friedman, J., Fredericks, W., Rauscher, F., 1999 In : Molecular and Cellular Biology. 19, 6, p. 4366-78

Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
Aagaard, L., Laible, G., Selenko, P., Schmid, M., Dorn, R., Schotta, G., Kuhfittig, S., Wolf, A., Lebersorger, A., Singh, P., Reuter, G., Jenuwein, T., 1999 In : EMBO Journal. 18, 7, p. 1923-38

M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis
Motzkus, D., Singh, P., Hoyer-Fender, S., 1999 In : Cytogenetic and Genome Research. 86, 1, p. 83-8

The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin
Doe, C., Wang, G., Chow, C., Fricker, M., Singh, P., Mellor, E., 1998 In : Nucleic Acids Research. 26, 18, p. 4222-9

The M31 gene has a complex developmentally regulated expression profile and may encode alternative protein products that possess diverse subcellular localisation patterns
Peterson, K., Wang, G., Horsley, D., Richardson, J., Sapienza, C., Latham, K., Singh, P., 1998 In : Journal of Experimental Zoology. 280, 4, p. 288-303

Chromatin complexes as aperiodic microcrystalline arrays that regulate genome organisation and expression
Singh, P., Huskisson, N., 1998 In : Genesis. 22, 1, p. 85-99

Modelling the activity of the Ultrabithorax parasegment-specific regulatory domains around their anterior boundaries
Singh, P., Brown, D., 1997 In : Journal of Theoretical Biology. 186, 4, p. 397-413

Structure of the chromatin binding (chromo) domain from mouse modifier protein 1
Ball, L., Murzina, N., Broadhurst, R., Raine, A., Archer, S., Stott, F., Murzin, A., Singh, P., Domaille, P., Laue, E., 1997 In : EMBO Journal. 16, 9, p. 2473-81

M33, a mammalian homologue of Drosophila Polycomb localises to euchromatin within interphase nuclei but is enriched within the centromeric heterochromatin of metaphase chromosomes
Wang, G., Horsley, D., Ma, A., Otte, A., Hutchings, A., Butcher, G., Singh, P., 1997 In : Cytogenetic and Genome Research. 78, 1, p. 50-5

M32, a murine homologue of Drosophila heterochromatin protein 1 (HP1), localises to euchromatin within interphase nuclei and is largely excluded from constitutive heterochromatin
Horsley, D., Hutchings, A., Butcher, G., Singh, P., 1996 In : Cytogenetic and Genome Research. 73, 4, p. 308-11

Cbx-rs2 (M31), a mouse homolog of the Drosophila Heterochromatin protein 1 gene, maps to distal chromosome 11 and is nonallelic to Om
Feil, R., Baldacci, P., Tarttelin, E., Rhodes, M., Singh, P., Reik, W., 1995 In : Mammalian Genome. 6, 7, p. 469-71

Molecular mechanisms of cellular determination: their relation to chromatin structure and parental imprinting
Singh, P., 1994 In : Journal of Cell Science. 107 ( Pt 10), p. 2653-68

A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin
Wreggett, K., Hill, F., James, P., Hutchings, A., Butcher, G., Singh, P., 1994 In : Cytogenetic and Genome Research. 66, 2, p. 99-103

Chromosomal localization of human homologs of the Drosophila heterochromatin protein 1 (HP1) gene
Chevillard, C., Reik, W., McDermott, M., Fontes, M., Mattei, M., Singh, P., 1993 In : Mammalian Genome. 4, 2, p. 124-6

The mouse has a Polycomb-like chromobox gene
Pearce, J., Singh, P., Gaunt, S., 1992 In : Development. 114, 4, p. 921-9

Cloning and expression of Drosophila HP1 homologs from a mealybug, Planococcus citri
Epstein, H., James, T., Singh, P., 1992 In : Journal of Cell Science. 101 ( Pt 2), p. 463-74

Mapping of two human homologs of a Drosophila heterochromatin protein gene to the X chromosome
Reik, W., Leversha, M., Waterfield, N., Singh, P., 1992 In : Mammalian Genome. 3, 11, p. 650-2

Mapping of a mouse homolog of a heterochromatin protein gene the X chromosome
Hamvas, R., Reik, W., Gaunt, S., Brown, S., Singh, P., 1992 In : Mammalian Genome. 2, 1, p. 72-5

A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants
Singh, P., Miller, J., Pearce, J., Kothary, R., Burton, R., Paro, R., James, T., Gaunt, S., 1991 In : Nucleic Acids Research. 19, 4, p. 789-94

Homeogene expression patterns and chromosomal imprinting
Gaunt, S., Singh, P., 1990 In : Trends in Genetics. 6, 7, p. 208-12

Rearing rats in a germ-free environment eliminates their odors of individuality
Singh, P., Herbert, J., Roser, B., Arnott, L., Tucker, D., Brown, R., 1990 In : Journal of Chemical Ecology. 16, 5, p. 1667-82

Genome imprinting and development in the mouse
Surani, M., Kothary, R., Allen, N., Singh, P., Fundele, R., Ferguson-Smith, A., Barton, S., 1990 In : Development (Cambridge, England). Supplement. p. 89-98

Class I and class II regions of the major histocompatibility complex both contribute to individual odors in congenic inbred strains of rats
Brown, R., Roser, B., Singh, P., 1989 In : Behavior Genetics. 19, 5, p. 659-74

A monoclonal antibody to a determinant of the rat T cell antigen receptor expressed by a minor subset of T cells
Kampinga, J., Kroese, F., Pol, G., Nieuwenhuis, P., Haag, F., Singh, P., Roser, B., Aspinall, R., 1989 In : International Immunology. 1, 3, p. 289-95

Class I transplantation antigens in solution in body fluids and in the urine. Individuality signals to the environment
Singh, P., Brown, R., Roser, B., 1988 In : Journal of Experimental Medicine. 168, 1, p. 195-211

MHC antigens in urine as olfactory recognition cues
Singh, P., Brown, R., Roser, B., 1987 In : Nature. 327, 6118, p. 161-4

The major histocompatibility complex and the chemosensory recognition of individuality in rats
Brown, R., Singh, P., Roser, B., 1987 In : Physiology and Behavior. 40, 1, p. 65-73