Prof. Tokay has 29 years of academic and research experience in the fields of biomedical research, clinical research and Biomedical teaching at 4 Universities in 4 different countries: Associate Professor of Human Anatomy at Xinjiang Medical University in China (13 years); Doctor and Postdoc at Rouen University in France (6 year); Principal Investigator and Assistant Professor of Physiology at Rostock University in Germany (8 years). Prof. Tokay also has administration and management experience at CLS, Nazarbayev University in Kazakhstan (2 years).
After graduation from Xinjiang Medical University, P.R. China in 1987, Prof. Tokay was appointed for an academic position in the same University. He participated in Anatomy teaching and several research projects of the University. In 1999, Prof. Tokay was honoured a Scholarship from “Chinese National Scholarship Council” and sent to France to complete a PhD program.
In 2005, after obtaining his PhD degree in Neurobiology with outstanding remarks (summa cum Laude), he was invited by University of Rostock / Germany to participate in a national research project granted by Federal Ministry for Education and Research of Germany. In 2009, Prof. Tokay was appointed for a permanent academic position at the University of Rostock.
Since July 2014, Prof. Tokay has been working at the Center for Life Science at Nazarbayev University as Deputy Director General on Science, Innovation and Academic Issues, and Head of Institute of Bioengineering, Regenerative Medicine and Neurophysiology, respectively.
RESEARCH INTERESTS
Regulation of neurotransmitter receptors and brain function in health and disease.
– To better understand the mechanisms of synaptic transmission and synaptic plasticity
– To investigate the role of glutamate receptors in learning and memory
Understanding the mechanisms of aging and neurodegeneration.
– To investigate the role of beta-amyloid on astrocyte and AD
To explore the impact of Reactive Oxygen Species (ROS) on aging and neurodegeneration.
– Development of new therapeutic strategies to neurological disorders
– To search for molecules to prevent and treat epilepsy and other neurodegenerative disorders
Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic RatsRehberg, M., Kirschstein, T., Guli, X., Müller, S., Rohde, M., Franz, D., Tokay, T., Köhling, R.,
2017 In : Neural Plasticity. 2017,
Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous SystemHan, B., Tokay, T., Zhang, G., Sun, P., Hou, S.,
2017 In : Oxidative Medicine and Cellular Longevity. 2017,
Power of PTEN/AKT: Molecular switch between tumor suppressors and oncogenesXie, Y., Naizabekov, S., Chen, Z., Tokay, T.,
2016 In : Oncology Letters. 12, 1, p. 375-378
Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsyMao, X., Tokay, T., Zhou, H., Jin, W.,
2016 In : Oncotarget. 7, 22, p. 33451-33460
P2Y receptor-mediated transient relaxation of rat longitudinal ileum preparations involves phospholipase C activation, intracellular Ca(2+) release and SK channel activationMader, F., Krause, L., Tokay, T., Hakenberg, O., Köhling, R., Kirschstein, T.,
2016 In : Acta Pharmacologica Sinica. 37, 5, p. 617-628
Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor functionWürdemann, T., Kersten, M., Tokay, T., Guli, X., Kober, M., Rohde, M., Porath, K., Sellmann, T., Bien, C., Köhling, R., Kirschstein, T.,
2016 In : Brain Research. 1633, p. 10-18
Pim-1 kinase as cancer drug target: An update (Review)Tursynbay, Y., Zhang, J., Li, Z., Tokay, T., Zhumadilov, Z., Wu, D., Xie, Y.,
2016 In : Biomedical Reports. 4, 2, p. 140-146
Status Epilepticus Enhances Depotentiation after Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent MannerGuli, X., Tokay, T., Kirschstein, T., Köhling, R.,
2016 In : Neural Plasticity. 2016,
Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex i mouse mutantsMayer, J., Reichart, G., Tokay, T., Lange, F., Baltrusch, S., Junghanss, C., Wolkenhauer, O., Jaster, R., Kunz, M., Tiedge, M., Ibrahim, S., Fuellen, G., Köhling, R.,
2015 In : PLoS One. 10, 4,
Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizuresMüller, L., Müller, S., Sellmann, T., Groeneweg, L., Tokay, T., Köhling, R., Kirschstein, T.,
2014 In : Epilepsy Research. 108, 1, p. 90-97
NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulationTokay, T., Kirschstein, T., Rohde, M., Zschorlich, V., Köhling, R.,
2014 In : Neural Plasticity. 2014,
Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2BMüller, L., Tokay, T., Porath, K., Köhling, R., Kirschstein, T.,
2013 In : Neurobiology of Disease. 54, p. 183-193
Impaired D-Serine-Mediated cotransmission mediates cognitive dysfunction in epilepsyKlatte, K., Kirschstein, T., Otte, D., Pothmann, L., Müller, L., Tokay, T., Kober, M., Uebachs, M., Zimmer, A., Beck, H.,
2013 In : Journal of Neuroscience. 33, 32, p. 13066-13080
Upregulation of presynaptic mGluR2, but not mGluR3 in the epileptic medial perforant pathRohde, J., Kirschstein, T., Wilkars, W., Müller, L., Tokay, T., Porath, K., Bender, R., Köhling, R.,
2012 In : Neuropharmacology. 62, 4, p. 1867-1873
ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapsesGuli, X., Tokay, T., Rohde, M., BenDer, R., Khling, R., Kirschstein, T.,
2012 In : Neural Plasticity. 2012,
The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: Involvement in cell proliferationJarry, M., Diallo, M., Lecointre, C., Desrues, L., Tokay, T., Chatenet, D., Leprince, J., Rossi, O., Vaudry, H., Tonon, M., Prézeau, L., Castel, H., Gandolfo, P.,
2010 In : Biochemical Journal. 428, 1, p. 113-124
GABAA receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapsesRohde, M., Tokay, T., Köhling, R., Kirschstein, T.,
2009 In : Neuroscience Letters. 467, 1, p. 20-25
HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapsesTokay, T., Rohde, M., Krabbe, S., Rehberg, M., Bender, R., Köhling, R., Kirschstein, T.,
2009 In : Learning and Memory. 16, 12, p. 769-776
Dopamine induces contraction in the proximal, but relaxation in the distal rat isolated small intestineKirschstein, T., Dammann, F., Klostermann, J., Rehberg, M., Tokay, T., Schubert, R., Köhling, R.,
2009 In : Neuroscience Letters. 465, 1, p. 21-26
High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal slicesTokay, T., Holl, N., Kirschstein, T., Zschorlich, V., Köhling, R.,
2009 In : Neuroscience Letters. 461, 2, p. 150-154
High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscleKirschstein, T., Rehberg, M., Bajorat, R., Tokay, T., Porath, K., Köhling, R.,
2009 In : Acta Pharmacologica Sinica. 30, 8, p. 1123-1131
Beta-amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N-formyl peptide receptorsTokay, T., Hachem, R., Masmoudi-Kouki, O., Gandolfo, P., Desrues, L., Leprince, J., Castel, H., Diallo, M., Amri, M., Vaudry, H., Tonon, M.,
2008 In : GLIA. 56, 13, p. 1380-1389
Somatostatin down-regulates the expression and release of endozepines from cultured rat astrocytes via distinct receptor subtypesMasmoudi, O., Gandolfo, P., Tokay, T., Leprince, J., Ravni, A., Vaudry, H., Tonon, M.,
2005 In : Journal of Neurochemistry. 94, 3, p. 561-571
Beta-amyloid peptides stimulate endozepine biosynthesis in cultured rat astrocytesTokay, T., Masmoudi, O., Gandolfo, P., Leprince, J., Pelletier, G., Vaudry, H., Tonon, M.,
2005 In : Journal of Neurochemistry. 94, 3, p. 607-616
Anti-inflammatory effects and mechanism of berberineJiang, J., Geng, D., Tursonjan, T., Liu, F.,
1998 In : Chinese Pharmacological Bulletin. 14, 5, p. 434-437
