Darkhan Utepbergenov
Department
School of Science and Technology, Chemistry Title
Assistant Professor Office
7.112 Email
darkhan.utepbergenov@nu.edu.kz Phone
+7 (7172) 709107Dr. Darkhan Utepbergenov is an assistant professor in the department of Chemistry, Nazarbayev University. After graduation from the Department of Natural Sciences of Novosibirsk State University in 1996 he was awarded a scholarship from Daimler-Benz Foundation and moved to Germany to work on his Ph.D. in Research Institute of Molecular Pharmacology in Berlin. After obtaining Ph.D. degree in 2000 he worked as a postdoctoral researcher in Germany for two years and later moved to United States where he continued his research in top public universities (University of North Carolina and University of Virginia).
Dr. Darkhan Utepbergenov authored 25 scientific publications in international peer-reviewed journals and supervised dozens of undergraduate, graduate and Ph.D. students in Germany and U.S.
RESEARCH INTERESTS
Biochemistry, Protein chemistry, Protein tags, Bioanalytics and protein X-ray crystallography.
Full list of publications can be found on this page.
Bacterial expression, purification and in Vitro phosphorylation of full-length ribosomal S6 kinase 2 (RSK2)
Utepbergenov, D., Hennig, P., Derewenda, U., Artamonov, M., Somlyo, A., Derewenda, Z., 2016 In : PLoS One. 11, 10,
The p90 Ribosomal S6 Kinase (RSK) Is a Mediator of Smooth Muscle Contractility
Artamonov, M., Momotani, K., Utepbergenov, D., Franke, A., Khromov, A., Derewenda, Z., Somlyo, A., 2013 In : PLoS One. 8, 3,
Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): Structure of its complex with the N-terminal domain of RSK2 at 1.8Å resolution
Derewenda, U., Artamonov, M., Szukalska, G., Utepbergenov, D., Olekhnovich, N., Parikh, H., Kellogg, G., Somlyo, A., Derewenda, Z., 2013 In : Acta Crystallographica Section D: Biological Crystallography. 69, 2, p. 266-275
The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides
Utepbergenov, D., Derewenda, Z., 2013 In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 7, p. 1285-1291
Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor
Utepbergenov, D., Derewenda, U., Olekhnovich, N., Szukalska, G., Banerjee, B., Hilinski, M., Lannigan, D., Stukenberg, P., Derewenda, Z., 2012 In : Biochemistry. 51, 33, p. 6499-6510
P63RhoGEF couples G αq/11-mediated signaling to Ca 2+ sensitization of vascular smooth muscle contractility
Momotani, K., Artamonov, M., Utepbergenov, D., Derewenda, U., Derewenda, Z., Somlyo, A., 2011 In : Circulation Research. 109, 9, p. 993-1002
Structural features and chaperone activity of the NudC protein family
Zheng, M., Cierpicki, T., Burdette, A., Utepbergenov, D., Janczyk, P., Derewenda, U., Stukenberg, P., Caldwell, K., Derewenda, Z., 2011 In : Journal of Molecular Biology. 409, 5, p. 722-741
The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties
Fanning, A., Little, B., Rahner, C., Utepbergenov, D., Walther, Z., Anderson, J., 2007 In : Molecular Biology of the Cell. 18, 3, p. 721-731
Dimerization of the scaffolding protein ZO-1 through the second PDZ domain
Utepbergenov, D., Fanning, A., Anderson, J., 2006 In : Journal of Biological Chemistry. 281, 34, p. 24671-24677
Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms
Andreeva, A., Piontek, J., Blasig, I., Utepbergenov, D., 2006 In : International Journal of Biochemistry and Cell Biology. 38, 2, p. 222-233
The tight junction protein occludin and the adherens junction protein α-catenin share a common interaction mechanism with ZO-1 *
Müller, S., Portwich, M., Schmidt, A., Utepbergenov, D., Huber, O., Blasig, I., Krause, G., 2005 In : Journal of Biological Chemistry. 280, 5, p. 3747-3756
Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: Potential mechanism of tight junction regulation
Schmidt, A., Utepbergenov, D., Mueller, S., Beyermann, M., Schneider-Mergener, J., Krause, G., Blasig, I., 2004 In : Cellular and Molecular Life Sciences. 61, 11, p. 1354-1365
Direct Demonstration of Association of the Blood-Brain Barrier Proteins ZO-1 and Occludin Using Surface Plasmon Resonance Spectroscopy; Effect of SIN-1
Schmidt, A., Utepbergenov, D., Krause, G., Blasig, I., 2003 Blood-Spinal Cord and Brain Barriers in Health and Disease. Elsevier, p. 11-17
Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin
Schmidt, A., Utepbergenov, D., Krause, G., Blasig, I., 2001 In : Biochemical and Biophysical Research Communications. 288, 5, p. 1194-1199
Protein Kinase C Regulates the Phosphorylation and Cellular Localization of Occludin
Andreeva, A., Krause, E., Müller, E., Blasig, I., Utepbergenov, D., 2001 In : Journal of Biological Chemistry. 276, 42, p. 38480-38486
An optical method for the detection of oxidative stress using protein-RNA interaction
Lisdat, F., Utepbergenov, D., Haseloff, R., Blasig, I., Stöcklein, W., Scheller, F., Brigelius-Flohé, R., 2001 In : Analytical Chemistry. 73, 5, p. 957-962
·NO and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier
Blasig, I., Giese, H., Schroeter, M., Sporbert, A., Utepbergenov, D., Buchwalow, I., Neubert, K., Schönfelder, G., Freyer, D., Schimke, I., Siems, W., Paul, M., Haseloff, R., Blasig, R., 2001 In : Microvascular Research. 62, 2, p. 114-127
Thiol-induced nitric oxide release from 3-halogeno-3,4-dihydrodiazete 1,2-dioxides
Kirilyuk, I., Utepbergenov, D., Mazhukin, D., Fechner, K., Mertsch, K., Khramtsov, V., Blasig, I., Haseloff, R., 1998 In : Journal of Medicinal Chemistry. 41, 7, p. 1027-1033
Nitric oxide protects blood-brain barrier in vitro from hypoxia/reoxygenation-mediated injury
Utepbergenov, D., Mertsch, K., Sporbert, A., Tenz, K., Paul, M., Haseloff, R., Blasig, I., 1998 In : FEBS Letters. 424, 3, p. 197-201
Cytokine- and hypoxia-induced lipid peroxidation in astrocytes
Blasig, I., Sporbert, A., Utepbergenov, D., Schroeter, M., Mertsch, K., Haseloff, R., 1998 In : International Journal of Clinical Pharmacology and Therapeutics. 36, 2, p. 112-113
Synthesis and spin trapping applications of 2,2-dimethyl-d6-4-methyl-2H-imidazole-1-oxide-1-15N
Haseloff, R., Kirilyuk, I., Dikalov, S., Khramtsov, V., Utepbergenov, D., Blasig, I., Grigor'ev, I., 1997 In : Free Radical Research. 26, 2, p. 159-168
Issledovaniia in vitro i in vivo proizvodnykh 1,2-diazetina i nitronilnitroksida v kachestve donorov i aktseptorov oksida azota.
Khramtsov, V., Utepbergenov, D., Vol'dman, I., Vlasenko, L., Markel', A., Kiriliuk, I., Grigor'ev, I., Mazhukin, D., Tikhonov, A., Volodarskii, D., 1996 In : Biokhimiya. 61, 10, p. 1731-1742
Unexpected transformation of 1,2-bis(N-methoxy-N-nitrosoamino)cycloalkanes: First synthesis of 4,5-dihydro-1,2,3-triazole 2-oxides
Khlestkin, V., Mazhukin, D., Tikhonov, A., Bagryanskaya, I., Gatilov, Y., Utepbergenov, D., Khramtsov, V., Volodarsky, L., 1996 In : Tetrahedron Letters. 37, 33, p. 5997-6000
In vitro and in vivo studies of the derivatives of 1,2-diazetine and nitronylnitroxide as donors and acceptors of nitric oxide
Khramtsov, V., Utepbergenov, D., Vol'dman, Y., Vlasenko, L., Markel', A., Kirilyuk, I., Grigor'ev, I., Mazhukin, D., Tikhonov, A., Volodarskij, L., 1996 In : Biokhimiya. 61, 7, p. 1731-1742
In vitro and in vivo studies of derivatives of 1,2-diazetine and nitronylnitroxide as donors and acceptors of nitric oxide
Khramtsov, V., Utepbergenov, D., Woldman, Y., Vlassenko, L., Markel, A., Kiriljuk, I., Grigor'ev, I., Mazhokin, D., Tikhonov, A., Volodarsky, L., 1996 In : Biochemistry (Moscow). 61, 10, p. 1223-1231
Kinetics of Nitric Oxide Liberation by 3,4-Dihydro-1,2-Diazete 1,2-Dioxides and Their Vasodilatory Properties in Vitro and in Vivo
Utepbergenov, D., Khramtsov, V., Vlassenko, L., Markel, A., Mazhukin, D., Tikhonov, A., Volodarsky, L., 1995 In : Biochemical and Biophysical Research Communications. 214, 3, p. 1023-1032
Spin Trapping of Nitric Oxide by Nitronylnitroxides: Measurement of the Activity of NO Synthase from Rat Cerebellum
Woldman, Y., Khramtsov, V., Grigorev, I., Kiriljuk, I., Utepbergenov, D., 1994 In : Biochemical and Biophysical Research Communications. 202, 1, p. 195-203
Utepbergenov, D., Hennig, P., Derewenda, U., Artamonov, M., Somlyo, A., Derewenda, Z., 2016 In : PLoS One. 11, 10,
The p90 Ribosomal S6 Kinase (RSK) Is a Mediator of Smooth Muscle Contractility
Artamonov, M., Momotani, K., Utepbergenov, D., Franke, A., Khromov, A., Derewenda, Z., Somlyo, A., 2013 In : PLoS One. 8, 3,
Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): Structure of its complex with the N-terminal domain of RSK2 at 1.8Å resolution
Derewenda, U., Artamonov, M., Szukalska, G., Utepbergenov, D., Olekhnovich, N., Parikh, H., Kellogg, G., Somlyo, A., Derewenda, Z., 2013 In : Acta Crystallographica Section D: Biological Crystallography. 69, 2, p. 266-275
The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides
Utepbergenov, D., Derewenda, Z., 2013 In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 7, p. 1285-1291
Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor
Utepbergenov, D., Derewenda, U., Olekhnovich, N., Szukalska, G., Banerjee, B., Hilinski, M., Lannigan, D., Stukenberg, P., Derewenda, Z., 2012 In : Biochemistry. 51, 33, p. 6499-6510
P63RhoGEF couples G αq/11-mediated signaling to Ca 2+ sensitization of vascular smooth muscle contractility
Momotani, K., Artamonov, M., Utepbergenov, D., Derewenda, U., Derewenda, Z., Somlyo, A., 2011 In : Circulation Research. 109, 9, p. 993-1002
Structural features and chaperone activity of the NudC protein family
Zheng, M., Cierpicki, T., Burdette, A., Utepbergenov, D., Janczyk, P., Derewenda, U., Stukenberg, P., Caldwell, K., Derewenda, Z., 2011 In : Journal of Molecular Biology. 409, 5, p. 722-741
The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties
Fanning, A., Little, B., Rahner, C., Utepbergenov, D., Walther, Z., Anderson, J., 2007 In : Molecular Biology of the Cell. 18, 3, p. 721-731
Dimerization of the scaffolding protein ZO-1 through the second PDZ domain
Utepbergenov, D., Fanning, A., Anderson, J., 2006 In : Journal of Biological Chemistry. 281, 34, p. 24671-24677
Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms
Andreeva, A., Piontek, J., Blasig, I., Utepbergenov, D., 2006 In : International Journal of Biochemistry and Cell Biology. 38, 2, p. 222-233
The tight junction protein occludin and the adherens junction protein α-catenin share a common interaction mechanism with ZO-1 *
Müller, S., Portwich, M., Schmidt, A., Utepbergenov, D., Huber, O., Blasig, I., Krause, G., 2005 In : Journal of Biological Chemistry. 280, 5, p. 3747-3756
Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: Potential mechanism of tight junction regulation
Schmidt, A., Utepbergenov, D., Mueller, S., Beyermann, M., Schneider-Mergener, J., Krause, G., Blasig, I., 2004 In : Cellular and Molecular Life Sciences. 61, 11, p. 1354-1365
Direct Demonstration of Association of the Blood-Brain Barrier Proteins ZO-1 and Occludin Using Surface Plasmon Resonance Spectroscopy; Effect of SIN-1
Schmidt, A., Utepbergenov, D., Krause, G., Blasig, I., 2003 Blood-Spinal Cord and Brain Barriers in Health and Disease. Elsevier, p. 11-17
Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin
Schmidt, A., Utepbergenov, D., Krause, G., Blasig, I., 2001 In : Biochemical and Biophysical Research Communications. 288, 5, p. 1194-1199
Protein Kinase C Regulates the Phosphorylation and Cellular Localization of Occludin
Andreeva, A., Krause, E., Müller, E., Blasig, I., Utepbergenov, D., 2001 In : Journal of Biological Chemistry. 276, 42, p. 38480-38486
An optical method for the detection of oxidative stress using protein-RNA interaction
Lisdat, F., Utepbergenov, D., Haseloff, R., Blasig, I., Stöcklein, W., Scheller, F., Brigelius-Flohé, R., 2001 In : Analytical Chemistry. 73, 5, p. 957-962
·NO and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier
Blasig, I., Giese, H., Schroeter, M., Sporbert, A., Utepbergenov, D., Buchwalow, I., Neubert, K., Schönfelder, G., Freyer, D., Schimke, I., Siems, W., Paul, M., Haseloff, R., Blasig, R., 2001 In : Microvascular Research. 62, 2, p. 114-127
Thiol-induced nitric oxide release from 3-halogeno-3,4-dihydrodiazete 1,2-dioxides
Kirilyuk, I., Utepbergenov, D., Mazhukin, D., Fechner, K., Mertsch, K., Khramtsov, V., Blasig, I., Haseloff, R., 1998 In : Journal of Medicinal Chemistry. 41, 7, p. 1027-1033
Nitric oxide protects blood-brain barrier in vitro from hypoxia/reoxygenation-mediated injury
Utepbergenov, D., Mertsch, K., Sporbert, A., Tenz, K., Paul, M., Haseloff, R., Blasig, I., 1998 In : FEBS Letters. 424, 3, p. 197-201
Cytokine- and hypoxia-induced lipid peroxidation in astrocytes
Blasig, I., Sporbert, A., Utepbergenov, D., Schroeter, M., Mertsch, K., Haseloff, R., 1998 In : International Journal of Clinical Pharmacology and Therapeutics. 36, 2, p. 112-113
Synthesis and spin trapping applications of 2,2-dimethyl-d6-4-methyl-2H-imidazole-1-oxide-1-15N
Haseloff, R., Kirilyuk, I., Dikalov, S., Khramtsov, V., Utepbergenov, D., Blasig, I., Grigor'ev, I., 1997 In : Free Radical Research. 26, 2, p. 159-168
Issledovaniia in vitro i in vivo proizvodnykh 1,2-diazetina i nitronilnitroksida v kachestve donorov i aktseptorov oksida azota.
Khramtsov, V., Utepbergenov, D., Vol'dman, I., Vlasenko, L., Markel', A., Kiriliuk, I., Grigor'ev, I., Mazhukin, D., Tikhonov, A., Volodarskii, D., 1996 In : Biokhimiya. 61, 10, p. 1731-1742
Unexpected transformation of 1,2-bis(N-methoxy-N-nitrosoamino)cycloalkanes: First synthesis of 4,5-dihydro-1,2,3-triazole 2-oxides
Khlestkin, V., Mazhukin, D., Tikhonov, A., Bagryanskaya, I., Gatilov, Y., Utepbergenov, D., Khramtsov, V., Volodarsky, L., 1996 In : Tetrahedron Letters. 37, 33, p. 5997-6000
In vitro and in vivo studies of the derivatives of 1,2-diazetine and nitronylnitroxide as donors and acceptors of nitric oxide
Khramtsov, V., Utepbergenov, D., Vol'dman, Y., Vlasenko, L., Markel', A., Kirilyuk, I., Grigor'ev, I., Mazhukin, D., Tikhonov, A., Volodarskij, L., 1996 In : Biokhimiya. 61, 7, p. 1731-1742
In vitro and in vivo studies of derivatives of 1,2-diazetine and nitronylnitroxide as donors and acceptors of nitric oxide
Khramtsov, V., Utepbergenov, D., Woldman, Y., Vlassenko, L., Markel, A., Kiriljuk, I., Grigor'ev, I., Mazhokin, D., Tikhonov, A., Volodarsky, L., 1996 In : Biochemistry (Moscow). 61, 10, p. 1223-1231
Kinetics of Nitric Oxide Liberation by 3,4-Dihydro-1,2-Diazete 1,2-Dioxides and Their Vasodilatory Properties in Vitro and in Vivo
Utepbergenov, D., Khramtsov, V., Vlassenko, L., Markel, A., Mazhukin, D., Tikhonov, A., Volodarsky, L., 1995 In : Biochemical and Biophysical Research Communications. 214, 3, p. 1023-1032
Spin Trapping of Nitric Oxide by Nitronylnitroxides: Measurement of the Activity of NO Synthase from Rat Cerebellum
Woldman, Y., Khramtsov, V., Grigorev, I., Kiriljuk, I., Utepbergenov, D., 1994 In : Biochemical and Biophysical Research Communications. 202, 1, p. 195-203