In 1994, Dr. Arman Saparov immigrated to the United States and completed his Post-Doctoral training at the School of Medicine at the University of Alabama at Birmingham. In 1998, he was promoted to a permanent faculty position at the same institution.
From 2001 to 2007, Dr. Saparov held various leadership positions at Xenogen Biosciences, located in greater Princeton area, New Jersey. During his employment at Xenogen, he led research projects in the areas of immunology, inflammation, cell technology and genetic engineering. The main purpose of his research was to determine the molecular mechanisms of disease pathogenesis and to define the effect of genes on the initiation and development of various diseases including cardiovascular diseases, lung inflammation, rheumatoid arthritis, diabetes, encephalitis and others. Dr. Saparov also managed research that tested new drugs for the treatment of the diseases mentioned above. In his projects, he collaborated with some of the largest pharmaceutical companies of the world, including Pfizer, Merck, Bristol-Myers Squibb and Schering Plough.
In 2007, Dr. Saparov joined Partners HealthCare System, a not-for-profit integrated health system founded by Massachusetts General Hospital and Brigham and Women’s Hospital, teaching affiliates of Harvard Medical School and a global leader in quality patient care, medical education and biomedical research.
Before joining Nazarbayev University in 2010, Dr. Saparov served as an Executive Director of the National Medical Holding (NMH), a joint-stock company that managed six state-of-the-art hospitals in Astana. He was a member of the Governing Board at NMH and Chairman of the Board of Directors at the Medical University of Astana. At Nazarbayev University, Dr. Saparov served as a Director of a newly created Directorate of the Integrated Academic Health System, an Acting Dean of NU Foundation, a Pre-Medicine Program Director, an Acting Chair of the Biology Department at the School of Science and Technology, and a Chief Executive Director at the School of Medicine.
The pathological progression following myocardial infarction (MI) is very complex and involves a number of cell populations including cells localized within the heart, as well as cells recruited from circulation and other tissues that participate in inflammatory and reparative processes. These cells, with their secretory factors, have pleiotropic effects that depend on the stage of inflammation and regeneration. Excessive inflammation leads to enlargement of the infarction site, pathological remodeling and eventually, heart dysfunction. Stem cell therapy represents a unique and innovative approach to ameliorate oxidative stress and inflammation caused by ischemic heart disease. Consequently, it is crucial to understand the crosstalk between stem cells and other cells involved in post-MI cardiac tissue repair, especially immune cells, in order to harness the beneficial effects of the immune response following MI and further improve stem cell-mediated cardiac regeneration.
Dr. Saparov’s current areas of research interests are:
- engineering an optimal cellular preconditioning system to maximize the in vitro production of cardioprotective and immunomodulatory factors by human perivascular stem cells (PSC);
- the benefits of using a novel controlled release system to deliver human PSC-derived cardioprotective and immunomodulatory factors for the treatment of MI;
- mechanisms by which human PSC-derived factors mediate their effects and ameliorate inflammation following MI.
Jumabay, M., Zhumabai, J., Mansurov, N., Niklason, K., Guihard, P., Cubberly, M., Fogelman, A., Iruela-Arispe, L., Yao, Y., Saparov, A., Boström, K., 2018 In : Journal of Cellular Physiology. 233, 3, p. 1812-1822
Role of the immune system in cardiac tissue damage and repair following myocardial infarction
Saparov, A., Ogay, V., Nurgozhin, T., Chen, W., Mansurov, N., Issabekova, A., Zhakupova, J., 2017 In : Inflammation Research. 66, 9, p. 739-751
A controlled release system for simultaneous delivery of three human perivascular stem cell-derived factors for tissue repair and regeneration
Mansurov, N., Chen, W., Awada, H., Huard, J., Wang, Y., Saparov, A., 2017 In : Journal of Tissue Engineering and Regenerative Medicine.
Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune Response
Saparov, A., Ogay, V., Nurgozhin, T., Jumabay, M., Chen, W., 2016 In : Stem Cells International. 2016, p. 3924858
Isolation of blood-vessel-derived multipotent precursors from human skeletal muscle
Chen, W., Saparov, A., Corselli, M., Crisan, M., Zheng, B., Péault, B., Huard, J., 2014 In : Journal of Visualized Experiments. 90, p. e51195
Human pericytes for ischemic heart repair
Chen, C., Okada, M., Proto, J., Gao, X., Sekiya, N., Beckman, S., Corselli, M., Crisan, M., Saparov, A., Tobita, K., Peault, B., Huard, J., 2013 In : Stem Cells. 31, 2, p. 305-316
The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair.
Saparov, A., Chen, C., Beckman, S., Wang, Y., Huard, J., 2013 In : International Journal of Molecular Sciences. 14, 8, p. 16258-16279
An extensive phenotypic characterization of the hTNFα transgenic mice
Hayward, M., Jones, B., Saparov, A., Hain, H., Trillat, A., Bunzel, M., Corona, A., Li-Wang, B., Strenkowski, B., Giordano, C., Shen, H., Arcamone, E., Weidlick, J., Vilensky, M., Tugusheva, M., Felkner, R., Campbell, W., Rao, Y., Grass, D., Buiakova, O., 2007 In : BMC Physiology. 7,
Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells
Hurez, V., Saparov, A., Tousson, A., Fuller, M., Kubo, T., Oliver, J., Weaver, B., Weaver, C., 2003 In : Journal of Experimental Medicine. 198, 1, p. 123-132
Unexpected characteristics of the IFN-γ reporters in nontransformed T cells
Zhu, H., Yang, J., Murphy, T., Ouyang, W., Wagner, F., Saparov, A., Weaver, C., Murphy, K., 2001 In : Journal of Immunology. 167, 2, p. 855-865
Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function
Saparov, A., Wagner, F., Zheng, R., Oliver, J., Maeda, H., Hockett, R., Weaver, C., 1999 In : Immunity. 11, 3, p. 271-280
Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR
Saparov, A., Kraus, L., Cong, Y., Marwill, J., Xu, X., Elson, C., Weaver, C., 1999 In : International Immunology. 11, 8, p. 1253-1263
Heterogeneity in the clonal T cell response: Implications for models of T cell activation and cytokine phenotype development
Weaver, C., Saparov, A., Kraus, L., Rogers, W., Hockett, R., Bucy, R., 1998 In : Immunologic Research. 17, 3, p. 279-302
Interferon-producing ability and natural cytotoxic activity of lymphocytes of local and system immunity in patients with ulcer and gastric cancer
Tsoy, I., Bulegenova, M., Dzhumagulova, A., Saparov, A., 1997 In : Immunologiya. 6, p. 40-43
Single-cell analyses of CD4+ T cells from αβ T cell receptor-transgenic mice: A distinct mucosal cytokine phenotype in the absence of transgene-specific antigen
Saparov, A., Elson, C., Devore-Carter, D., Bucy, R., Weaver, C., 1997 In : European Journal of Immunology. 27, 7, p. 1774-1781
Tolerization of ovalbumin-specific αβ-tcr transgenic cells in adoptively transferred mice by the feeding of ovalbumin
Weaver, C., Saparov, A., Marwill, J., Elson, C., Buoy, R., Kraus, L., 1996 In : FASEB Journal. 10, 6,
In vivo cytokine production and antibody isotype profiles reflect the TR1 or TN2 phenotype of adoptivley transferred αβ-tcr transgenic cells
Kraus, L., Marwiil, J., Saparov, A., Rogers, W., Bucy, R., Weaver, C., 1996 In : FASEB Journal. 10, 6,
In vivo analysis of CD4+ T cell responses to oral immunization
Saparov, A., Kraus, L., Marwill, J., Bucy, R., Elson, C., Weaver, C., 1996 In : FASEB Journal. 10, 6,
Immunostimuliruiushchee deĭstvie laktobakteriĭ na tsitotoksichnost' estestvennykh kletok killerov i produktsiiu interferona
Tsoĭ, I., Saparov, A., Timofeeva, I., Dzhumagulova, A., Bulegenova, M., Seksenbaev, B., 1994 In : Zhurnal mikrobiologii, epidemiologii, i immunobiologii. 6, p. 112-3
Immunomodifitsiruiushchie svoĭstva zhenskogo, korov'ego i kobyl'ego moloka
Kurmangalinov, S., Aĭdarkhanov, B., Sharmanov, A., Taspolatov, B., Chuvakova, T., Saparov, A., 1992 In : Pediatriya - Zhurnal im G.N. Speranskogo. 4-6, p. 65-8
Povyshenie aktivnosti estestvennykh killerov u krys s nedostatochnost'yu vitamina A
Saparov, A., Kon, I., Sharmanov, A., 1989 In : Voprosy Pitaniia. 2, p. 30-2