Educational Background
Ph.D., Free University Berlin, Berlin, Germany
Postdoctoral:
- Brennwald Lab, Department of Cell Biology, University of North Carolina, Chapel Hill, US
- Xiaowei Lu Lab, Department of Cell Biology, University of Virginia, School of Medicine
Positions
2017 – current, Assistant Professor, Department of Biology, Nazarbayev University, School of Science and Technology
2014 – 2017, Research Scientist, Department of Neuroscience, University of Virginia, School of Medicine
Research Interests
Our perception of sound depends on the highly specialized hair cells interdigitated with supporting cells that together form a sensory epithelium of the inner ear. We are born with approximately 16,000 sensory hair cells in the cochlea of the inner ear. As we age, this surprisingly small number of sensory cell progressively decreases due to genetic and environmental factors, such as exposure to loud sounds, bacterial and viral infections and ototoxic drugs, including aminoglycoside antibiotics and the anti-cancer drug, cisplatin. Because supporting cells in mammals lost their ability to regenerate hair cells, the gradual hair cell loss during our lifespan leads to ultimate deafness. Hearing loss impacts well-being of 360 million people worldwide and has huge socioeconomic impact. Our ultimate goal is to unravel the molecular mechanisms that impede the ability of mammalian supporting cells to regenerate hair cells. Understanding of these molecular mechanisms would allow the development of new gene therapy strategies for hair cell regeneration.
PTK7-Src Signaling at Epithelial Cell Contacts Mediates Spatial Organization of Actomyosin and Planar Cell PolarityAndreeva, A., Lee, J., Lohia, M., Wu, X., Macara, I., Lu, X.,
2014 In : Developmental Cell. 29, 1, p. 20-33
PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epitheliumLee, J., Andreeva, A., Sipe, C., Liu, L., Cheng, A., Lu, X.,
2012 In : Current Biology. 22, 11, p. 956-966
Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanismHattendorf, D., Andreeva, A., Gangar, A., Brennwald, P., Weis, W.,
2007 In : Nature. 446, 7135, p. 567-571
The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4pGrosshans, B., Andreeva, A., Gangar, A., Niessen, S., Yates, J., Brennwald, P., Novick, P.,
2006 In : Journal of Cell Biology. 172, 1, p. 55-66
Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoformsAndreeva, A., Piontek, J., Blasig, I., Utepbergenov, D.,
2006 In : International Journal of Biochemistry and Cell Biology. 38, 2, p. 222-233
Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular functionGangar, A., Rossi, G., Andreeva, A., Hales, R., Brennwald, P.,
2005 In : Current Biology. 15, 12, p. 1136-1142
Protein Kinase C Regulates the Phosphorylation and Cellular Localization of OccludinAndreeva, A., Krause, E., Müller, E., Blasig, I., Utepbergenov, D.,
2001 In : Journal of Biological Chemistry. 276, 42, p. 38480-38486
Oligonucleotides and oligonucleotide-binding proteins of cerebrospinal fluidKuligina, E., Andreeva, A., Mogel'nitskii, A., Kit, Y., Yakubov, L., Rikhter, V., Vlasov, V.,
1999 In : Doklady Akademii Nauk. 364, 6, p. 832-834
Oligonucleotide-cell surface protein complexes are trafficking into cell nucleusShestova, O., Andreeva, A., Vlasov, V., Yakubov, L.,
1999 In : Doklady Akademii Nauk. 368, 2, p. 264-267
Participation of specific cell surface proteins in nucleic acids trafficking into cellYakubov, L., Shestova, O., Andreeva, A., Vlasov, V.,
1998 In : Doklady Akademii Nauk. 361, 4, p. 550-553
The extracellular domain of CD4 receptor possesses a protein kinase activityYakubov, L., Kit, Y., Richter, V., Andreeva, A., Karamyshev, V., Stein, C., Vlassov, V.,
1998 In : FEBS Letters. 431, 1, p. 45-48
Kindly nucleic acids binding receptor: Isolation and propertiesYakubov, L., Andreeva, A., Karamyshev, V., Vlasov, V.,
1996 In : Doklady Akademii Nauk. 350, 3, p. 414-417
