Anna Andreeva

Department
School of Science and Technology, National Laboratory Astana, Laboratory of bioinformatics and computational systems biology, Immunobiology Laboratory, Biology
Title
Assistant Professor
Office
7.106
Email
anna.andreeva@nu.edu.kz
Phone
9194497576

Educational Background

 

Ph.D., Free University Berlin, Berlin, Germany

Postdoctoral:

  • Brennwald Lab, Department of Cell Biology, University of North Carolina, Chapel Hill, US
  • Xiaowei Lu Lab, Department of Cell Biology, University of Virginia, School of Medicine

 

Positions

 

2017 – current, Assistant Professor, Department of Biology, Nazarbayev University, School of Science and Technology

2014 – 2017, Research Scientist, Department of Neuroscience, University of Virginia, School of Medicine

 

Research Interests

 

Our perception of sound depends on the highly specialized hair cells interdigitated with supporting cells that together form a sensory epithelium of the inner ear. We are born with approximately 16,000 sensory hair cells in the cochlea of the inner ear.  As we age, this surprisingly small number of sensory cell progressively decreases due to genetic and environmental factors, such as exposure to loud sounds, bacterial and viral infections and ototoxic drugs, including aminoglycoside antibiotics and the anti-cancer drug, cisplatin. Because supporting cells in mammals lost their ability to regenerate hair cells, the gradual hair cell loss during our lifespan leads to ultimate deafness. Hearing loss impacts well-being of 360 million people worldwide and has huge socioeconomic impact. Our ultimate goal is to unravel the molecular mechanisms that impede the ability of mammalian supporting cells to regenerate hair cells. Understanding of these molecular mechanisms would allow the development of new gene therapy strategies for hair cell regeneration.